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Description for Protein PIP4K2B

phosphatidylinositol-5-phosphate 4-kinase, type II, beta
5 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(microparticles: 1; platelet: 3)
Summary:
The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • PIPKc: Phosphatidylinositol phosphate kinases
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.1.149
    KEGG - Orthology:
    K00920
    KEGG - Pathway(s):
    hsa00562; hsa04070; hsa04810
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Diphosphoinositide kinase; EC 2.7.1.68; Phosphatidylinositol-4-phosphate 5-kinase type II beta isoform a; Phosphatidylinositol-4-phosphate 5-kinase type II beta isoform b; PIP5KIIB; PIP5KIIbeta; Pip4k2B; PTDINS(4)P-5-kinase; 1-phosphatidylinositol-4-phosphate kinase
    Approved Symbol:
    PIP4K2B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04463 Entrez Gene ID: 8396 OMIM ID: 603261 Swissprot Accession: P78356;