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Description for Protein CASP6

caspase 6, apoptosis-related cysteine peptidase
33 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(platelet: 4; secretome: 1)
Summary:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CASc: Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.22.59
    KEGG - Orthology:
    K04396
    KEGG - Pathway(s):
    hsa04210
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Apoptotic protease MCH2; MCH2; Caspase 6 isoform alpha preproprotein; Caspase 6 isoform beta
    Approved Symbol:
    CASP6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03321 Entrez Gene ID: 839 OMIM ID: 601532 Swissprot Accession: P55212;