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Description for Protein MAD1L1

MAD1 mitotic arrest deficient-like 1 (yeast)
21 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06638
    KEGG - Pathway(s):
    hsa04110; hsa04914
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MAD1 like1; Mitotic arrest deficient 1; TAX binding protein 181; TXBP181; Mitotic checkpoint MAD1 protein homolog; HsMAD1; PIG9; TP53I9; MAD1; Tumor protein p53 inducible protein 9; Mitotic spindle assembly checkpoint protein MAD1
    Approved Symbol:
    MAD1L1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 17
    Human (de-) phosphorylation sites: 17; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Lymphoma, somatic(Pd);
  • Prostate cancer, somatic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04065 Entrez Gene ID: 8379 OMIM ID: 602686 Swissprot Accession: Q9Y6D9;