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Description for Protein FERMT3

fermitin family member 3
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 13/2)
(alpha granules: 1; membrane: 2; microparticles: 1; phosphoproteome: 1; platelet: 8; secretome: 2; undefined: 1)
Summary:
Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PH: Pleckstrin homology domain.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    URP2; KIND3; Kindlin 3; MIG2B; MGC10966; UNC-112 related protein 2 short form; UNC-112 related protein 2 long form
    Approved Symbol:
    FERMT3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; Platelet phosphorylation sites: 2
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07440 Entrez Gene ID: 83706 OMIM ID: 607901 Swissprot Accession: Q86UX7;