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Description for Protein CASP4

caspase 4, apoptosis-related cysteine peptidase
36 total interacting proteins; 21 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CASc: Caspase, interleukin-1 beta converting enzyme (ICE) homologues
  • CARD: Caspase recruitment domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.22.57
    KEGG - Orthology:
    K04394
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    apoptotic cysteine protease Mih1/TX; TX; ICH-2; Mih1/TX; ICEREL-II; ICE (rel) II; Caspase 4 isoform alpha precursor; Caspase 4 isoform delta; Caspase 4 isoform gamma
    Approved Symbol:
    CASP4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04047 Entrez Gene ID: 837 OMIM ID: 602664 Swissprot Accession: P49662; A2NHM0; A2NHL8;