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Description for Protein CASP3

caspase 3, apoptosis-related cysteine peptidase
143 total interacting proteins; 79 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/1)
(microparticles: 1; platelet: 4; secretome: 1)
Summary:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CASc: Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.22.56
    KEGG - Orthology:
    K02187
    KEGG - Pathway(s):
    hsa04010; hsa04115; hsa04210; hsa04650; hsa05010; hsa05012; hsa05014; hsa05016; hsa05120; hsa05200; hsa05210; hsa05416
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Yama protein; PARP cleavage protease; Cysteine protease CPP32; SREBP cleavage activity 1; CPP32; CPP32B; SCA-1; Caspase 3; Apopain; Procaspase3; EC 3.4.22
    Approved Symbol:
    CASP3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate(db);
  • (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate(db);
  • 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE(db);
  • 2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID(db);
  • 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID(db);
  • 5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid(db);
  • methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate(db);
  • Minocycline(db);
  • N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide(db);
  • [N-(3-DIBENZYLCARBAMOYL-OXIRANECARBONYL)-HYDRAZINO]-ACETIC ACID(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02799 Entrez Gene ID: 836 OMIM ID: 600636 Swissprot Accession: P42574;