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Description for Protein RASSF5

Ras association (RalGDS/AF-6) domain family member 5
24 total interacting proteins; 18 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • RA: Ras association (RalGDS/AF-6) domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08015
    KEGG - Pathway(s):
    hsa04670; hsa05200; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    RP11-343H5.1; MGC10823; Maxp1; NORE1; RAPL; RASSF3; Rap1-binding protein; Ras association (RalGDS/AF-6) domain family 5 isoform D; Ras association (RalGDS/AF-6) domain family 5 isoform A; Ras association (RalGDS/AF-6) domain family 5 isoform B; Ras association (RalGDS/AF-6) domain family 5 isoform C
    Approved Symbol:
    RASSF5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06117 Entrez Gene ID: 83593 OMIM ID: 607020 Swissprot Accession: Q8WWW0;