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Description for Protein CASP2

caspase 2, apoptosis-related cysteine peptidase
29 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The proteolytic cleavage of this protein is induced by a variety of apoptotic stimuli. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
  • CASc: Caspase, interleukin-1 beta converting enzyme (ICE) homologues
  • CARD: Caspase recruitment domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.22.55
    KEGG - Orthology:
    K02186
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    ICH 1 protease; NEDD2 apoptosis regulatory gene; ICH1; NEDD2; ICH 1L; ICH 1L/1S; Caspase 2 isoform 3; Caspase 2 isoform 4; Caspase 2 isoform 1
    Approved Symbol:
    CASP2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02800 Entrez Gene ID: 835 OMIM ID: 600639 Swissprot Accession: Q9BZL0; P42575;