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Description for Protein TCF7L1

transcription factor 7-like 1 (T-cell specific, HMG-box)
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • HMG: high mobility group
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04490
    KEGG - Pathway(s):
    hsa04310; hsa04520; hsa04916; hsa05200; hsa05210; hsa05213; hsa05215; hsa05216; hsa05217; hsa05221; hsa05412
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Transcription factor 3; TCF3; HMG box transcription factor 3
    Approved Symbol:
    TCF7L1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06874 Entrez Gene ID: 83439 OMIM ID: 604652 Swissprot Accession: Q9HCS4;