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Description for Protein CARS

cysteinyl-tRNA synthetase
5 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 6; secretome: 6)
Summary:
This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.1.1.16
    KEGG - Orthology:
    K01883
    KEGG - Pathway(s):
    hsa00970
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Cysteinyl tRNA synthetase isoform a; Cysteinyl tRNA synthetase isoform c; Cysteinyl tRNA synthetase isoform d; Cysteinyl tRNA synthetase isoform b; Cysteine tRNA ligase; CysRS; Cysteine translase; EC 6.1.1.16; MGC 11246
    Approved Symbol:
    CARS
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 18
    Human (de-) phosphorylation sites: 18; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • L-Cysteine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00464 Entrez Gene ID: 833 OMIM ID: 123859 Swissprot Accession: A8MVQ3; P49589; Q5HYE4;