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Description for Protein CAST

calpastatin
10 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 3)
Summary:
The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04281
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Calpastatin isoform b; Calpastatin isoform c; Calpastatin isoform a; Calpain inhibitor; Sperm BS 17 component; BS-17; MGC9402; Heart type calpastatin
    Approved Symbol:
    CAST
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 322
    Human (de-) phosphorylation sites: 322; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Calcium(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
    00233_12(0)
    00233_11(0)
    00233_10(0)
  • Isoform 9 : 0
  • Isoform 8 : 0
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00233 Entrez Gene ID: 831 OMIM ID: 114090 Swissprot Accession: P20810; Q59HE3;