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Description for Protein ARID1A

AT rich interactive domain 1A (SWI-like)
16 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • BRIGHT: BRIGHT, ARID (A/T-rich interaction domain) domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K11653
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Chromosome 1 open reading frame 4; SWI/SNF related, matrix-associated, actin-dependent regulator of chromatin, subfamily F, member 1; C1ORF4 B120 GENE; B120; OSA1 nuclear protein; P270; BM029; BAF250; C1orf4; BRG1-associated factor 250a; SWI/SNF complex protein p270; chromatin remodeling factor p250; SMARCF1; AT rich interactive domain 1A (SWI- like) isoform b; AT rich interactive domain 1A (SWI- like) isoform a
    Approved Symbol:
    ARID1A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 42
    Human (de-) phosphorylation sites: 42; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04319 Entrez Gene ID: 8289 OMIM ID: 603024 Swissprot Accession: O14497;