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Description for Protein KDM5C

lysine (K)-specific demethylase 5C
13 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PHD: PHD zinc finger
  • JmjN: Small domain found in the jumonji family of transcription factors
  • JMJC: A domain family that is part of the cupin metalloenzyme superfamily.
  • BRIGHT: BRIGHT, ARID (A/T-rich interaction domain) domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.14.11.-
    KEGG - Orthology:
    K11446
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Xe169 protein; SMC homolog X chromosome; XE169; Protein SmcX; Smcy homolog, X-linked; Selected cDNA on X; Jumonji, AT rich interactive domain 1C; SMCX; RP11-258C19.2; DXS1272E; MRXJ; MRXSJ; Jumonji/ARID domain-containing protein 1C
    Approved Symbol:
    KDM5C
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02442 Entrez Gene ID: 8242 OMIM ID: 314690 Swissprot Accession: P41229; B4E3I2;