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Description for Protein CAPN2

calpain 2, (m/II) large subunit
19 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 1; undefined: 1)
Summary:
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CYSPC: Calpain-like thiol protease family.
  • CALPAIN_III: Rad18-like CCHC zinc finger
  • EF: EF-hand, calcium binding motif
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.22.53
    KEGG - Orthology:
    K03853
    KEGG - Pathway(s):
    hsa04210; hsa04510; hsa05010
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    calpain, large polypeptide L2; calcium-activated neutral proteinase; mCANP; CANPL2; CANPml
    Approved Symbol:
    CAPN2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00254 Entrez Gene ID: 824 OMIM ID: 114230 Swissprot Accession: P17655; Q59EF6; B4DN77;