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Description for Protein USP11

ubiquitin specific peptidase 11
59 total interacting proteins; 17 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 2)
Summary:
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • UCH: Ubiquitin carboxyl-terminal hydrolase
  • DUSP: Domain in ubiquitin-specific proteases.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.2.15
    KEGG - Orthology:
    K11835
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    UHX1; Ubiquitin carboxyl terminal hydrolase 11; Ubiquitin carboxyl terminal hydrolase X-linked; Ubiquitin specific processing protease 11; Deubiquitinating enzyme 11; Ubiquitin thiolesterase 11
    Approved Symbol:
    USP11
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02081 Entrez Gene ID: 8237 OMIM ID: 300050 Swissprot Accession: P51784;