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Description for Protein NCOA3

nuclear receptor coactivator 3
77 total interacting proteins; 32 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PAS: PAS domain
  • CC: Coiled Coil
  • HLH: helix loop helix domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.3.1.48
    KEGG - Orthology:
    K11256
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Nuclear receptor coactivator 3; AIB1; ACTR; Thyroid hormone receptor activator molecule 1; TRAM1; EC 2.3.1.48; NCoA-3; Amplified in breast cancer-1 protein; RAC-3; Receptor-associated coactivator 3; Steroid receptor coactivator protein 3; SRC-3; CBP-interacting protein; pCIP; Nuclear receptor coactivator 3 isoform a; Nuclear receptor coactivator 3 isoform b
    Approved Symbol:
    NCOA3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 36
    Human (de-) phosphorylation sites: 36; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03570 Entrez Gene ID: 8202 OMIM ID: 601937 Swissprot Accession: Q9Y6Q9;