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Description for Protein CAMK2G

calcium/calmodulin-dependent protein kinase II gamma
29 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Six alternatively spliced variants that encode six different isoforms have been characterized to date. Additional alternative splice variants that encode different isoforms have been described, but their full-length nature has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.17
    KEGG - Orthology:
    K04515
    KEGG - Pathway(s):
    hsa04012; hsa04020; hsa04114; hsa04310; hsa04720; hsa04722; hsa04740; hsa04912; hsa04916; hsa05214
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CAMKG; Calcium/Calmodulin dependent protein kinase 2 gamma; Cam-Kinase 2 Gamma Chain; CAMK; CAMK2; CaM kinase 2; EC 2.7.1.123; Calcium/Calmodulin dependent Protein Kinase Ii Gamma Isoform 2; Calcium/Calmodulin dependent Protein Kinase Ii Gamma Isoform 3; Calcium/Calmodulin dependent Protein Kinase Ii Gamma Isoform 5; Calcium/Calmodulin dependent Protein Kinase Ii Gamma Isoform 6; Calcium/Calmodulin dependent Protein Kinase Ii Gamma Isoform 4; Calcium/calmodulin-dependent Protein kinase II gamma isoform 1
    Approved Symbol:
    CAMK2G
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 44
    Human (de-) phosphorylation sites: 44; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 38
    Human phosphorylation targets: 18; Predicted platelet targets: 20
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03672 Entrez Gene ID: 818 OMIM ID: 602123 Swissprot Accession: Q13555; O00561; Q13280;