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Description for Protein CAMK2D

calcium/calmodulin-dependent protein kinase II delta
12 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns. (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.17
    KEGG - Orthology:
    K04515
    KEGG - Pathway(s):
    hsa04012; hsa04020; hsa04114; hsa04310; hsa04720; hsa04722; hsa04740; hsa04912; hsa04916; hsa05214
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MGC44911; CaM kinase II delta chain; CaM kinase II delta subunit; Calcium/calmodulin dependent protein kinase II-delta; CAMKD; EC 2.7.1.123; Calcium/calmodulin-dependent protein kinase II delta isoform 3; Calcium/calmodulin-dependent protein kinase II delta isoform 2
    Approved Symbol:
    CAMK2D
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 31
    Human (de-) phosphorylation sites: 31; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 7
    Human phosphorylation targets: 7; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE(db);
  • [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09653 Entrez Gene ID: 817 OMIM ID: 607708 Swissprot Accession: Q13557; A8MVS8;