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Description for Protein AKAP1

A kinase (PRKA) anchor protein 1
14 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • KH: K homology RNA-binding domain
  • TM: Transmembrane domain
  • TUDOR: Tudor domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    A kinase anchor protein, 149KD; AKAP149; A kinase anchor protein 1, mitochondrial; Protein kinase A anchoring protein 1; Dual specificity A kinase anchoring protein 1; Spermatid A kinase anchor protein 84; S AKAP84; AKAP121; AKAP84; PRKA1; D AKAP 1; A kinase anchor protein 1 isoform 1
    Approved Symbol:
    AKAP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 17
    Human (de-) phosphorylation sites: 17; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 03905 Entrez Gene ID: 8165 OMIM ID: 602449 Swissprot Accession: Q92667;