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Description for Protein CAMK2B

calcium/calmodulin-dependent protein kinase II beta
14 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.17
    KEGG - Orthology:
    K04515
    KEGG - Pathway(s):
    hsa04012; hsa04020; hsa04114; hsa04310; hsa04720; hsa04722; hsa04740; hsa04912; hsa04916; hsa05214
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Calcium/calmodulin dependent protein kinase IIB isoform 8; Calcium/calmodulin-dependent protein kinase IIB isoform 2; Calcium/calmodulin dependent protein kinase IIB isoform 3; Calcium/calmodulin dependent protein kinase IIB isoform 4; Calcium/calmodulin dependent protein kinase IIB isoform 5; Calcium/calmodulin dependent protein kinase IIB isoform 6; Calcium/calmodulin dependent protein kinase IIB isoform 7; CAM2; CAMK2; MGC29528; EC: 2.7.1.123; CaMK II beta subunit; CaM kinase II beta chain; Proline rich calmodulin dependent protein kinase; Calcium/calmodulin dependent protein kinase II beta; Calcium/calmodulin dependent protein kinase type II beta chain; Calcium/calmodulin-dependent protein kinase IIB isoform 1
    Approved Symbol:
    CAMK2B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 27
    Human (de-) phosphorylation sites: 27; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 7
    Human phosphorylation targets: 7; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 8 : 0
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 12127 Entrez Gene ID: 816 OMIM ID: 607707 Swissprot Accession: Q13554; A4D2K5; A4D2J9;