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Description for Protein PLA2G12A

phospholipase A2, group XIIA
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.1.4
    KEGG - Orthology:
    K01047
    KEGG - Pathway(s):
    hsa00564; hsa00565; hsa00590; hsa00591; hsa00592; hsa01100; hsa04010; hsa04270; hsa04370; hsa04664; hsa04730; hsa04912
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Group XIIA secretory phospholipase A2; Phosphatidylcholine 2-acylhydrolase GXII; GXII sPLA2; FKSG38 protein; EC 3.1.1.4
    Approved Symbol:
    PLA2G12A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 17858 Entrez Gene ID: 81579 OMIM ID: 611652 Swissprot Accession: Q542Y6; Q9BZM1;