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Description for Protein HM13

histocompatibility (minor) 13
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(membrane: 1; platelet: 7)
Summary:
The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.99.-
    KEGG - Orthology:
    K09595
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Signal peptide peptidase; Histocompatibility 13; Presenilin like protein 3; Minor histocompatibility antigen H13; SPP; Minor histocompatibility antigen 13 isoform 3; Minor histocompatibility antigen 13 isoform 2; Minor histocompatibility antigen 13 isoform 1; Minor histocompatibility antigen 13 isoform 4; H13; IMP1; PSL3; IMPAS; PSENL3; MSTP086; dJ324O17.1; Intramembrane protease; EC 3.4.99; hIMP1 protein
    Approved Symbol:
    HM13
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 3
  • Isoform 3 : 7
  • Isoform 2 : 7
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 06166 Entrez Gene ID: 81502 OMIM ID: 607106 Swissprot Accession: Q8TCT9; Q15K36;