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Description for Protein CAMK2A

calcium/calmodulin-dependent protein kinase II alpha
43 total interacting proteins; 15 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.17
    KEGG - Orthology:
    K04515
    KEGG - Pathway(s):
    hsa04012; hsa04020; hsa04114; hsa04310; hsa04720; hsa04722; hsa04740; hsa04912; hsa04916; hsa05214
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Calcium/calmodulin dependent protein kinase type II alpha; CaM-kinase II alpha chain; CaM kinase II alpha subunit; KIAA0968 protein; Calcium/calmodulin-dependent protein kinase II alpha-B subunit; Calcium/calmodulin-dependent protein kinase IIA isoform 2; Calcium/calmodulin-dependent protein kinase IIA isoform 1
    Approved Symbol:
    CAMK2A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 17
    Human (de-) phosphorylation sites: 17; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 50
    Human phosphorylation targets: 44; Predicted platelet targets: 6
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}(db);
  • 1,4-Dithiothreitol(db);
  • Hexatantalum Dodecabromide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06532 Entrez Gene ID: 815 OMIM ID: 114078 Swissprot Accession: Q8IWE0; A8K161; Q9UQM7;