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Description for Protein TAF15

TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
15 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and chromosome 9, where the gene for the nuclear receptor CSMF is located, result in a gene fusion product that is an RNA binding protein associated with a subset of extraskeletal myxoid chondrosarcomas. Two transcripts encoding different isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RRM: RNA recognition motif
  • ZnF_RBZ: Zinc finger domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    TBP-associated factor 15 isoform 1; TBP-associated factor 15 isoform 2; TAFII68; RBP56; TAF2N; RBP56/CSMF fusion gene; RNA binding protein 56; TAF15 RNA polymerase II; TATA box binding protein (TBP) associated factor, 68 kD; TATA box binding protein associated factor 2N; TBP associated factor RNA polymerase II 68-KD; TATA binding protein associated factor 2N
    Approved Symbol:
    TAF15
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 47
    Human (de-) phosphorylation sites: 47; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09031 Entrez Gene ID: 8148 OMIM ID: 601574 Swissprot Accession: Q92804; Q86X94;