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Description for Protein KCNH6

potassium voltage-gated channel, subfamily H (eag-related), member 6
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 4)
Summary:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • CNMP: Cyclic nucleotide-monophosphate binding domain
  • CC: Coiled Coil
  • PAC: Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04909
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Eag-related gene member 2; EAG-RELATED GENE 2; Potassium voltage-gated channel, subfamily H, member 6 isoform 1; Potassium voltage-gated channel, subfamily H, member 6 isoform 2; ERG2; HERG2; Kv11.2; Potassium voltage gated channel subfamily H eag related member 6; Potassium voltage gated channel subfamily H member 6 eag related protein 2 Eag related gene member 2; Ether a go go related protein 2; Eag related protein 2; Ether a go go related gene potassium channel 2; Voltage gated potassium channel subunit Kv11.2
    Approved Symbol:
    KCNH6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Doxazosin(db);
  • Ibutilide(db);
  • Miconazole(db);
  • Prazosin(db);
  • Terazosin(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 5
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 16294 Entrez Gene ID: 81033 OMIM ID: 608168 Swissprot Accession: Q9H252;