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Description for Protein TUBB1

tubulin, beta 1
3 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 10/2)
(alpha granules: 1; cAMP/cGMP binding: 1; membrane: 2; platelet: 7; secretome: 1; undefined: 1)
Summary:
This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y. (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • TUBULIN: Tubulin/FtsZ family, GTPase domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07375
    KEGG - Pathway(s):
    hsa04540; hsa05130
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    dJ543J19.4; Beta tubulin 1 class VI
    Approved Symbol:
    TUBB1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Cabazitaxel(db);
  • Colchicine(db);
  • Docetaxel(db);
  • Epothilone B(db);
  • Epothilone D(db);
  • Paclitaxel(db);
  • Vindesine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 18243 Entrez Gene ID: 81027 OMIM ID: 612901 Swissprot Accession: Q9H4B7;