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Description for Protein USP5

ubiquitin specific peptidase 5 (isopeptidase T)
7 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(secretome: 2)
Summary:
Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • ZnF_UBP: Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger
  • CC: Coiled Coil
  • UBA: Ubiquitin associated domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.2.15
    KEGG - Orthology:
    K11836
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Ubiquitin isopeptidase T; ISOT; Ubiquitin carboxyl terminal hydrolase 5; Ubiquitin thiolesterase 5; Ubiquitin specific processing protease 5; Deubiquitinating enzyme 5; Ubiquitin specific peptidase 5 isoform 1; Ubiquitin specific peptidase 5 isoform 2
    Approved Symbol:
    USP5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 13
    Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03265 Entrez Gene ID: 8078 OMIM ID: 601447 Swissprot Accession: P45974;