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Description for Protein TSEN2

tRNA splicing endonuclease 2 homolog (S. cerevisiae)
5 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.1.27.9
KEGG - Orthology:
K01170
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
HsSen2 protein; tRNA intron endonuclease SEN2; tRNA splicing endonuclease subunit SEN2; KIAA1679
Approved Symbol:
TSEN2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 5
Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 10576 Entrez Gene ID: 80746 OMIM ID: 608753 Swissprot Accession: C9IZI7; Q8NCE0; B7Z6K1;