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Description for Protein COASY

CoA synthase
3 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(phosphoproteome: 1; platelet: 7; undefined: 1)
Summary:
Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. COASY is a bifunctional enzyme that catalyzes the 2 last steps in CoA synthesis. These activities are performed by 2 separate enzymes, phosphopantetheine adenylyltransferase (PPAT; EC 2.7.7.3) and dephospho-CoA kinase (DPCK; EC 2.7.1.24), in prokaryotes (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.1.24; 2.7.7.3
    KEGG - Orthology:
    K02318
    KEGG - Pathway(s):
    hsa00770; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Bifunctional phosphopantetheine adenylyl transferase; Dephospho CoA kinase; NBP; DPCK; PPAT; UKR1; pOV2; Nucleotide binding protein phosphopantetheine adenylyltransferase; Dephospho CoA pyrophosphorylase; Coenzyme A synthase isoform a; Coenzyme A synthase isoform b
    Approved Symbol:
    COASY
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 12
    Human (de-) phosphorylation sites: 12; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 13080 Entrez Gene ID: 80347 OMIM ID: 609855 Swissprot Accession: Q13057;