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Description for Protein ADAM33

ADAM metallopeptidase domain 33
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • REP: Replication protein
  • ACR: ADAM Cysteine-Rich Domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.24.-
    KEGG - Orthology:
    K08616
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Disintegrin and reprolysin metalloproteinase family protein; A disintegrin and metalloproteinase domain 33; Metalloprotease disintegrin; Disintegrin and metalloproteinase domain 33 isoform beta preproprotein; Disintegrin and metalloproteinase domain 33 isoform alpha; ADAM metallopeptidase domain 33; FLJ35308; FLJ36751; MGC71889; DJ964F7.1; MGC149823; DKFZp434K0521
    Approved Symbol:
    ADAM33
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alpha-D-Mannose(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 06173 Entrez Gene ID: 80332 OMIM ID: 607114 Swissprot Accession: Q9BZ11;