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Description for Protein PDGFD

platelet derived growth factor D
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(secretome: 2)
Summary:
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • PDGF: Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  • CUB: Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05450
    KEGG - Pathway(s):
    hsa04060; hsa04510; hsa04540; hsa04810; hsa05215; hsa05218
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Platelet derived growth factor D isoform 1; Platelet derived growth factor D isoform 2; IEGF; MSTP036; SCDGFB; MGC26867; Iris expressed growth factor; Spinal cord derived growth factor B
    Approved Symbol:
    PDGFD
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 17830 Entrez Gene ID: 80310 OMIM ID: 609673 Swissprot Accession: Q9GZP0;