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Description for Protein STAM

signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
10 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 2)
Summary:
This gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein contains a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). This protein associates with JAK3 and JAK2 kinases via its ITAM region, and is phosphorylated by the JAK kinases upon cytokine stimulation, which suggests the function of this protein is as an adaptor molecule involved in the downstream signaling of cytokine receptors. HGS/HRS (hepatocyte grwoth factor-regulated tyrosine kinase substrate) has been found to bind and counteract the function of this protein. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • UIM: Ubiquitin-interacting motif.
  • SH3: Src homology 3 domains
  • CC: Coiled Coil
  • ITAM: Immunoreceptor tyrosine-based activation motif
  • VHS: Domain present in VPS-27, Hrs and STAM
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04705
    KEGG - Pathway(s):
    hsa04144; hsa04630
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Signal transducing adaptor molecule 1
    Approved Symbol:
    STAM
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03542 Entrez Gene ID: 8027 OMIM ID: 601899 Swissprot Accession: Q92783;