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Description for Protein PREX2

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
(PubMed Links)
Domains and Motifs:
  • PH: Pleckstrin homology domain.
  • RHOGEF: Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
  • PDZ: Domain present in PSD-95, Dlg, and ZO-1/2.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    DEP.2; PREX2; P-REX2; 6230420N16rik; PtdIns(3,4,5) dependent rac exchanger 2; Phosphatidylinositol 3,4,5-trisphosphate-dependent RAC exchanger 2; P-REX2b; DEP domain containing 2 isoform b; DEP domain containing 2 isoform a
    Approved Symbol:
    PREX2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 13135 Entrez Gene ID: 80243 OMIM ID: 612139 Swissprot Accession: Q70Z35;