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Description for Protein LHX3

LIM homeobox 3
8 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member a large protein family which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene have been associated with a syndrome of combined pituitary hormone deficiency and rigid cervical spine. Two transcripts variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • HOX: Homeodomain
  • LIM: Zinc-binding domain present in Lin-11, Isl-1, Mec-3.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09374
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    LIM 3; M2-LHX3; DKFZp762A2013; LIM/homeodomain protein LHX3; LIM homeobox protein 3 isoform b; LIM homeobox protein 3 isoform a
    Approved Symbol:
    LHX3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Pituitary hormone deficiency, combined, with rigid cervical spine(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02783 Entrez Gene ID: 8022 OMIM ID: 600577 Swissprot Accession: Q9UBR4;