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Description for Protein NR4A3

nuclear receptor subfamily 4, group A, member 3
6 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ZnF_C4: c4 zinc finger in nuclear hormone receptors
  • HOLI: Ligand binding domain of hormone receptors
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08559
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    CHN; CSMF; MINOR; Nuclear hormone receptor NOR 1; Neuron derived orphan receptor 1; Chondrosarcoma, myxoid extraskeletal; Mitogen induced nuclear orphan receptor; Nuclear receptor subfamily 4, group A, member 3 isoform b; Nuclear receptor subfamily 4, group A, member 3 isoform a; Nuclear receptor subfamily 4, group A, member 3 isoform c; TEC; NOR1; Translocated in extraskeletal chondrosarcoma; Neuron derived orphan receptor; Orphan nuclear receptor NR4A3
    Approved Symbol:
    NR4A3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02766 Entrez Gene ID: 8013 OMIM ID: 600542 Swissprot Accession: Q92570;