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Description for Protein CALM1

calmodulin 1 (phosphorylase kinase, delta)
124 total interacting proteins; 57 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/1)
(membrane: 3; platelet: 12)
Summary:
This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene. (PubMed Links)
Domains and Motifs:
  • EF: EF-hand, calcium binding motif
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K02183
    KEGG - Pathway(s):
    hsa04020; hsa04070; hsa04114; hsa04270; hsa04720; hsa04722; hsa04740; hsa04744; hsa04910; hsa04912; hsa04916; hsa04970; hsa05010; hsa05214
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Phosphorylase kinase, delta; PHKD; CALML2; CAMI
    Approved Symbol:
    CALM1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE(db);
  • 2-Methyl-2,4-Pentanediol(db);
  • 2-Methyl-2-Propanol(db);
  • 3''-(Beta-Chloroethyl)-2'',4''-Dioxo-3, 5''-Spiro-Oxazolidino-4-Deacetoxy-Vinblastine(db);
  • Acetate Ion(db);
  • Aprindine(db);
  • Bepridil(db);
  • Cacodylate Ion(db);
  • Calcium(db);
  • Dibucaine(db);
  • Felodipine(db);
  • Flunarizine(db);
  • Fluphenazine(db);
  • Isoflurane(db);
  • Loperamide(db);
  • Melatonin(db);
  • MYRISTIC ACID(db);
  • N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide(db);
  • N-Trimethyllysine(db);
  • Nicardipine(db);
  • Nifedipine(db);
  • Perphenazine(db);
  • Phenoxybenzamine(db);
  • Pimozide(db);
  • Prenylamine(db);
  • Promethazine(db);
  • Trifluoperazine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00241 Entrez Gene ID: 801 OMIM ID: 114180 Swissprot Accession: Q96HY3; P62158; B4DJ51;