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Description for Protein SEMA6D

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • PSI: domain found in Plexins, Semaphorins and Integrins
  • SEMA: semaphorin domain
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06842
    KEGG - Pathway(s):
    hsa04360
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Sema domain, transmembrane domain and cytoplasmic domain 6D; FLJ11598 protein; KIAA1479 protein; Semaphorin 6D isoform 2; Semaphorin 6D isoform 6; Semaphorin 6D isoform 3; Semaphorin 6D isoform 1; Semaphorin 6D isoform 5; Semaphorin 6D isoform 4 precursor
    Approved Symbol:
    SEMA6D
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 13
    Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 6 : 0
  • Isoform 5 : 1
  • Isoform 4 : 1
  • Isoform 3 : 0
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 10221 Entrez Gene ID: 80031 OMIM ID: 609295 Swissprot Accession: Q8NFY4; A6NM95;