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Description for Protein SCD5

stearoyl-CoA desaturase 5
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 4)
Summary:
Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.14.19.1
    KEGG - Orthology:
    K00507
    KEGG - Pathway(s):
    hsa01040; hsa03320
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Acyl CoA desaturase 4; ACOD4; FLJ21032; FADS4; HSCD5; SCD2; SCD4; Stearoyl CoA desaturase 4; Stearoyl CoA desaturase 4 isoform b; Stearoyl CoA desaturase 4 isoform a
    Approved Symbol:
    SCD5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 4
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 09756 Entrez Gene ID: 79966 OMIM ID: 608370 Swissprot Accession: Q86SK9; Q86UC8;