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Description for Protein TUSC3

tumor suppressor candidate 3
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12669
    KEGG - Pathway(s):
    hsa00510; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Putative prostate cancer tumor repressor; D8S1992; MGC13453; Tumor suppressor candidate 3 isoform b; Tumor suppressor candidate 3 isoform a
    Approved Symbol:
    TUSC3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 5
  • Isoform 1 : 5
    • Additional Identifiers:

    HPRD: 03228 Entrez Gene ID: 7991 OMIM ID: 601385 Swissprot Accession: Q13454;