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Description for Protein NEK11

NIMA (never in mitosis gene a)- related kinase 11
3 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described. (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K08857
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Never in mitosis gene A related kinase 11; FLJ23495; Serine/threonine-protein kinase Nek11; EC 2.7.1.37; NimA-related protein kinase 11; NIMA (never in mitosis gene a)- related kinase 11 isoform 1; NIMA (never in mitosis gene a)- related kinase 11 isoform 2
    Approved Symbol:
    NEK11
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 1
    Human phosphorylation targets: 1; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 14821 Entrez Gene ID: 79858 OMIM ID: 609779 Swissprot Accession: Q8NG66; B4DM56;