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Description for Protein NHEJ1

nonhomologous end-joining factor 1
5 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K10980
KEGG - Pathway(s):
hsa03450
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
XLF; FLJ12610; XRCC4-like factor; Cernunnos; Protein cernunnos
Approved Symbol:
NHEJ1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 8
Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07784 Entrez Gene ID: 79840 OMIM ID: 611290 Swissprot Accession: Q9H9Q4;