Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein MYH14

myosin, heavy chain 14, non-muscle
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 4/0)
(alpha granules: 1; ATP binding: 1; membrane: 1; platelet: 2)
Summary:
This gene encodes a member of the myosin superfamily. Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • MYOSIN: Myosin. Large ATPases
  • IQ: Short calmodulin-binding motif containing conserved Ile and Gln residues.
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10352
    KEGG - Pathway(s):
    hsa04530; hsa04810; hsa05416
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    DFNA4; NHMCII; FLJ13881; KIAA2034; Myosin, heavy chain 14, nonmuscle; Nonmuscle myosin heavy chain IIC; NMHC IIC; Myosin, heavy chain 14 isoform 1
    Approved Symbol:
    MYH14
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 12
    Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (3aS)-3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one(db);
  • (3aS)-3a-hydroxy-5-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one(db);
  • (3aS)-3a-hydroxy-7-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one(db);
  • (S)-blebbistatin(db);
  • Adenosine-5'-Diphosphate(db);
  • Mant-Adp(db);
  • N-METHYL O-NITROPHENYL AMINOETHYLDIPHOSPHATE BERYLLIUM TRIFLUORIDE(db);
  • Pyrophosphate 2-(db);
  • Tetrafluoroaluminate Ion(db)

    Associated Genetic Diseases:

  • Deafness, autosomal dominant nonsyndromic sensorineural 4(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 10543 Entrez Gene ID: 79784 OMIM ID: 608568 Swissprot Accession: B3KWH4; Q7Z406; B0I1S2;