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Description for Protein PPCS

phosphopantothenoylcysteine synthetase
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 6; secretome: 1)
Summary:
Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCS (EC 6.3.2.5), one of the last enzymes in this pathway, converts phosphopantothenate to phosphopantothenoylcysteine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
6.3.2.5
KEGG - Orthology:
K01922
KEGG - Pathway(s):
hsa00770; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Phosphopantothenoylcysteine synthetase isoform a; Phosphopantothenoylcysteine synthetase isoform b; FLJ11838; MGC117357; MGC138220; RP11-163G10.1; Phosphopantothenate--cysteine ligase; EC 6.3.2.5; PPC synthetase
Approved Symbol:
PPCS
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 4
Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07760 Entrez Gene ID: 79717 OMIM ID: 609853 Swissprot Accession: Q9HAB8; Q5VVM0;