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Description for Protein NEIL1

nei endonuclease VIII-like 1 (E. coli)
3 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.2.2.-; 4.2.99.18
    KEGG - Orthology:
    K10567
    KEGG - Pathway(s):
    hsa03410
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    NEI1; hFPG1; FLJ22402; nei endonuclease VIII like 1; FPG1; Nei like 1; DNA glycosylase/AP lyase Neil1; DNA (apurinic or apyrimidinic site) lyase Neil1; NEH1
    Approved Symbol:
    NEIL1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Tris(Hydroxymethyl)Aminomethane(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 12314 Entrez Gene ID: 79661 OMIM ID: 608844 Swissprot Accession: Q96FI4;