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Description for Protein BIRC7

baculoviral IAP repeat-containing 7
7 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RING: Ring finger
  • BIR: Baculoviral inhibition of apoptosis protein repeat
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Kidney inhibitor of apoptosis protein; Melanoma inhibitor of apoptosis protein; Inhibitor of apoptosis protein, melanoma; MLIAP; Livin inhibitor of apoptosis; Inhibitor of apoptosis protein, kidney; KIAP; Livin; RNF50; Livin inhibitor of apoptosis isoform alpha; Livin inhibitor of apoptosis isoform beta
    Approved Symbol:
    BIRC7
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05761 Entrez Gene ID: 79444 OMIM ID: 605737 Swissprot Accession: Q96CA5;