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Description for Protein PLA2G7

phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.1.47
    KEGG - Orthology:
    K01062
    KEGG - Pathway(s):
    hsa00565; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PAFAH; Platelet activating factor acetylhydrolase, plasma; PAF 2 acylhydrolase; Lipoprotein associated phospholipase A2; Phospholipase A2 group 7; PAF acetylhydrolase; LDL associated phospholipase A2; LDL-PLA(2); 2-acetyl-1-alkylglycerophosphocholine esterase; 1-alkyl-2-acetylglycerophosphocholine esterase
    Approved Symbol:
    PLA2G7
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (1R)-1,2,2-TRIMETHYLPROPYL (R)-METHYLPHOSPHINATE(db)

    Associated Genetic Diseases:

  • Asthma and atopy, susceptibility to(Pd);
  • Platelet-activating factor acetylhydrolase deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03407 Entrez Gene ID: 7941 OMIM ID: 601690 Swissprot Accession: Q13093;