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Description for Protein HSD17B8

hydroxysteroid (17-beta) dehydrogenase 8
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 6)
Summary:
In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.1.1.62; 1.1.1.63
    KEGG - Orthology:
    K13370
    KEGG - Pathway(s):
    hsa00140; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Estradiol 17 beta dehydrogenase 8; 17-beta-HSD 8; FabG like; FABGL; Ke6 protein; Ke-6; HKE6; RING2
    Approved Symbol:
    HSD17B8
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2'-Monophosphoadenosine 5'-Diphosphoribose(db);
  • NADH(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03248 Entrez Gene ID: 7923 OMIM ID: 601417 Swissprot Accession: Q92506;