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Description for Protein BAT3

HLA-B associated transcript 3
67 total interacting proteins; 31 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/2)
(phosphoproteome: 1; platelet: 1; undefined: 1)
Summary:
This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
  • UBQ: Ubiquitin homologues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    D6S52E; Large proline rich protein BAT3; Scythe; HLA-B associated transcript-3 isoform b; G3; BAG6; HLA-B associated transcript-3 isoform a
    Approved Symbol:
    BAG6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 34
    Human (de-) phosphorylation sites: 34; Platelet phosphorylation sites: 2
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00808 Entrez Gene ID: 7917 OMIM ID: 142590 Swissprot Accession: P46379;