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Description for Protein ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.4.99.-
    KEGG - Orthology:
    K06614
    KEGG - Pathway(s):
    hsa00604
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PST1; PST; Alpha 2,8 sialyltransferase 8D; ST8Sia 4; CMP N acetylneuraminate poly alpha 2,8 sialyl transferase; SIAT8D; MGC34450; MGC61459; ST8SIA-IV; Polysialyltransferase-1; Alpha-2,8-sialyltransferase 8D; Sialyltransferase 8 (alpha-2, 8-polysialytransferase) D; Sialyltransferase 8D (alpha-2, 8-polysialyltransferase); CMP-N-acetylneuraminate-poly-alpha-2,8-sialyl transferase; ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 isoform a; ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 isoform b
    Approved Symbol:
    ST8SIA4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03970 Entrez Gene ID: 7903 OMIM ID: 602547 Swissprot Accession: Q92187; Q8N1F4;