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Description for Protein VKORC1

vitamin K epoxide reductase complex, subunit 1
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.1.4.1
    KEGG - Orthology:
    K05357
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    VKOR; MST134; MST576; UNQ308; VKCFD2; EDTP308; MGC2694; FLJ00289; Phylloquinone epoxide reductase; Vitamin K1 epoxide reductase; Vitamin K1 2,3 epoxide reductase subunit 1; Vitamin K epoxide reductase complex subunit 1 isoform 1; Vitamin K epoxide reductase complex subunit 1 isoform 2; EC 1.1.4.1
    Approved Symbol:
    VKORC1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Acenocoumarol(db);
  • Dicumarol(db);
  • Menadione(db);
  • Phenindione(db);
  • Phenprocoumon(db);
  • Warfarin(db)

    Associated Genetic Diseases:

  • Vitamin K-dependent clotting factors, combined deficiency of, 2(Pd);
  • Warfarin resistance(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 3
    • Additional Identifiers:

    HPRD: 10540 Entrez Gene ID: 79001 OMIM ID: 608547 Swissprot Accession: Q9BQB6; A6NIQ6;